Chemical Intermediate N-Chlorosuccinimide 99% CAS 128-09-6

• Customization: Available
• Grade Standard: Medicine Grade, Industrial Grade, Agriculture Grade
• Appearance: Solid
• Model NO.: 99%
• Certification: ISO
• CAS: 128-09-6
• Shelf life: 2 years
• Quality: TOP
• Content: Standard
• Transport Package: Follow Customer′s Request.
• Specification: GB/FAO/SGS
• Trademark: TOP AGRO
• Origin: Zhejiang, China
• HS Code: 2924
• Production Capacity: 1, 000 T/Year

Product Description

 

Product Description

 

Common Name	N-chlorosuccinimide
CAS Number	128-09-6	Molecular Weight	133.533
Density	1.5±0.1 g/cm3	Boiling Point	200.5±23.0 °C at 760 mmHg
Molecular Formula	C4H4ClNO2	Melting Point	148-150 °C(lit.)

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	200.5±23.0 °C at 760 mmHg
Melting Point	148-150 °C(lit.)
Molecular Formula	C4H4ClNO2
Molecular Weight	133.533
Flash Point	75.1±22.6 °C
Exact Mass	132.993057
PSA	37.38000
LogP	-0.87
Vapour Pressure	0.3±0.4 mmHg at 25°C
Index of Refraction	1.532

 

 

Packaging & Shipping

 

For liquid	200Ltr/drum, 20L/drum, 1L/bottle, 500ml/bottle, 250ml/bottle, 100ml/bottle.
For solid	25 kg/drum, 25kg/bag, 1kg/bag or on the requirement of client.
Delivery Detail	20-30days

 

Applications

 

N-Chlorosuccinimide (NCS) is a versatile chlorinating and oxidizing agent widely used in organic synthesis, pharmaceuticals, and industrial chemistry. Below are its key applications:

 

1. Organic Synthesis 

 Chlorination Reactions 

• Allylic/Benzylic Chlorination: Selectively chlorinates alkenes (e.g., cyclohexene → 3-chlorocyclohexene) and activated C-H bonds.

• Aromatic Chlorination: Chlorinates electron-rich aromatics (e.g., phenols, anilines).

• Heteroatom Chlorination: Converts thiols to disulfides or sulfonyl chlorides.

 Oxidation Reactions 

• Alcohols to Carbonyls: Mild oxidation of alcohols to aldehydes/ketones.

• Sulfides to Sulfoxides: Selective oxidation of thioethers.

 Functional Group Activation

• Used in Hofmann rearrangement (amide → amine) and Selman's reagent for epoxide formation.

 

2. Pharmaceutical & Medicinal Chemistry 

 Drug Intermediate Synthesis

• Key chlorination step in antibiotics (e.g., chloramphenicol derivatives) and antiviral drugs.
   Peptide Modification

• Chlorinates tryptophan residues in protein studies.

 

3. Polymer & Material Science 

 Polymer Modification

• Introduces chlorine into polystyrene or rubber for flame retardancy.
   Photoresist Chemistry

• Used in semiconductor lithography processes.

 

4. Industrial & Environmental Applications

 Water Disinfection

• Slow-release chlorine source for pool/spa treatment (alternative to bleach).
   Bleaching Agent

• Mild bleaching of textiles and pulp.

 

5. Other Uses 

 Gold Extraction

• Oxidizes gold ores in hydrometallurgical processes.
   Laboratory Reagent

• Standard chlorinating agent in academic research.

 

Key Properties

• Selectivity: Prefers allylic/benzylic positions over harsh free-radical chlorination.

• Solubility: Reacts in DCM, THF, or acetonitrile (insoluble in water).

• Safety: Releases Cl2 upon decomposition; handle in a fume hood.

Advantages Over Cl2

• Solid form (easier handling than gaseous chlorine).

• Controlled reactivity (reduces over-chlorination side reactions).

 

Summary

NCS is essential for:
 Selective chlorination (C-H bonds, aromatics)
 Pharmaceutical intermediates
 Polymer functionalization

Its mild yet effective reactivity makes it a preferred alternative to hazardous chlorine gas, though NBS is often chosen for bromination.

 

 

 

Company Profile

HANGZHOU TIANLONG BIOTECHNOLOGYCO.,LTD
ADD: NO.338, FENGQI EAST ROAD, HANGZHOU CITY, ZHEJANG PROVINCE, CHINA P.C:310020
 
 
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