| Customization: | Available |
|---|---|
| Grade Standard: | Medicine Grade, Industrial Grade, Agriculture Grade |
| Appearance: | Solid |
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| Common Name | N-iodosuccinimide | ||
|---|---|---|---|
| CAS Number | 516-12-1 | Molecular Weight | 224.984 |
| Density | 2.3±0.1 g/cm3 | Boiling Point | 249.6±23.0 °C at 760 mmHg |
| Molecular Formula | C4H4INO2 | Melting Point | 202-206 °C(lit.) |
| Density | 2.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 249.6±23.0 °C at 760 mmHg |
| Melting Point | 202-206 °C(lit.) |
| Molecular Formula | C4H4INO2 |
| Molecular Weight | 224.984 |
| Flash Point | 104.8±22.6 °C |
| Exact Mass | 224.928665 |
| PSA | 37.38000 |
| LogP | -0.21 |
| Vapour Pressure | 0.0±0.5 mmHg at 25°C |
| Index of Refraction | 1.653 |
| Storage condition | 2-8°C |
| Water Solubility | decomposes |
| For liquid | 200Ltr/drum, 20L/drum, 1L/bottle, 500ml/bottle, 250ml/bottle, 100ml/bottle. |
| For solid | 25 kg/drum, 25kg/bag, 1kg/bag or on the requirement of client. |
| Delivery Detail | 20-30days |
N-Iodosuccinimide (NIS) is a mild and selective iodinating agent widely used in organic synthesis, medicinal chemistry, and materials science. It serves as a safer alternative to molecular iodine (I2) due to its controlled reactivity and solid form. Below are its key applications:
Iodination Reactions
Electrophilic Aromatic Iodination: Selectively iodinates electron-rich aromatics (e.g., phenols, anilines).
Allylic/Benzylic Iodination: Converts alkenes to allyl iodides.
Heterocyclic Iodination: Used in functionalizing indoles, pyrroles, and other N-heterocycles.
Oxidation Reactions
Converts thioethers to sulfoxides or sulfones under mild conditions.
Oxidizes primary alcohols to aldehydes (alternative to Dess-Martin periodinane).
Cyclization & C-H Activation
Promotes iodoetherification (e.g., olefins to iodotetrahydrofurans).
Used in radical-mediated C-H iodination reactions.
Drug Intermediate Synthesis
Key reagent for iodinated APIs (e.g., thyroid hormones like thyroxine).
Introduces iodine into biologically active molecules for radiolabeling (e.g., PET imaging probes).
Peptide & Protein Modification
Iodinates tyrosine residues in antibody-drug conjugates (ADCs).
Conductive Polymer Synthesis
Dopant for polyacetylene and other conjugated polymers.
Photoresist Chemistry
Used in semiconductor lithography for pattern formation.
Radiolabeling
Prepares 125I-labeled compounds for diagnostic imaging.
Cross-Coupling Reactions
Generates aryl iodides for Suzuki, Heck, and Sonogashira couplings.
Selectivity: Prefers electron-rich sites (e.g., aromatics over alkanes).
Solubility: Reacts in DCM, THF, or DMF (insoluble in water).
Safety: Solid form reduces hazards compared to I2 (no volatile iodine vapors).
Controlled reactivity (less prone to over-iodination).
Easier handling (no corrosive vapors or staining).
NIS is indispensable for:
Selective iodination (aromatics, alkenes, heterocycles)
Pharmaceutical radiolabeling
Polymer doping & electronics
Its mildness and versatility make it a staple in synthetic chemistry, though NBS/NCS are preferred for bromination/chlorination.
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